A survey of bancroftian filariasis for microfilariae & circulating antigenaemia in two villages of Madhya Pradesh.
نویسندگان
چکیده
BACKGROUND & OBJECTIVE The estimation of filariasis prevalence in Panna district of Madhya Pradesh was so far relied upon clinical and night blood smear examination. However, night blood smear examination fails to detect the infection in individuals having low parasitaemia and cryptic filarial infection. The present study was undertaken to re-evaluate the prevalence of filariasis in two villages of Panna district by Og4C3 ELISA. METHODS The study was carried out during 2002-2003 in two villages (namely Pista and Taroni) of Panna district, Madhya Pradesh. Clinical examination was performed according to WHO criteria to classify filarial disease. Night blood smears collected during 20:00 to 00:00 h were examined to detect microfilariae (Mf). For estimation of circulating filarial antigen (CFA) by Og4C3 ELISA, 2 ml blood was collected from each individual by venepuncture. RESULTS With Og4C3 ELISA, 38 per cent serum samples of village Pista (n=332) and 47.7 per cent from village Taroni (n=88) were found positive for CFA. The overall disease rate was (243/ 420) 57.9 per cent by CFA while it was (182/420) 43.3 per cent by night blood smear examination. A total of 14.5 per cent individuals were having cryptic filarial infection detected by CFA. INTERPRETATION & CONCLUSION The study emphasizes the use of CFA estimation being a sensitive and specific diagnostic tool for the evaluation of the true prevalence of the disease. The high CFA prevalence in the study area necessitates early intervention measures to check its transmission.
منابع مشابه
Vector control complements mass drug administration against bancroftian filariasis in Tirukoilur, India.
OBJECTIVE To determine the role of vector control in further decreasing the transmission of bancroftian filariasis achieved by mass drug administration and the long-term impact on filariometric indices. METHODS Three rounds of annual mass drug administration, with diethylcarbamazine and ivermectin, were complemented by vector control (mainly using polystyrene beads) in villages of Tirukoilur,...
متن کاملHydrocele Estimation: A Parameter for Filariasis Prevalence
The estimation of filariasis prevalence in the past was relied upon clinical and microfilariae examination by night blood smear. Recently in the nineties with the introduction of Og4C3 ELISA, antigen detection became the accepted methodology for estimating filariasis prevalence. However these methods are costly and/or require laboratory processing. Hydrocele in males is one of the clinical mani...
متن کاملDifferential recognition of a protective filarial antigen by antibodies from humans with bancroftian filariasis.
The objectives of this study were to identify filarial antigens which induce enhanced clearance of circulating microfilariae and to establish if human antibody reactivity with these molecules correlates with the apparent parasite burdens of residents of an endemic area of Bancroftian filariasis. Mice immunized with an extract of Brugia malayi microfilariae develop IgG antibodies to four major f...
متن کاملPresence of Wolbachia endosymbionts in microfilariae of Wuchereria bancrofti (Spirurida: Onchocercidae) from different geographical regions in India.
In view of the recent discovery of rickettsial endosymbionts, Wolbachia in lymphatic filarial parasites, Wuchereria bancrofti and Brugia malayi and subsequently of their vital role in the survival and development of the latter, antibiotics such as tetracycline are being suggested for the treatment of lymphatic filariasis, by way of eliminating the endosymbiont. But, it is essential to assess th...
متن کاملConcomitant infections of Plasmodium falciparum and Wuchereria bancrofti on the Kenyan coast
BACKGROUND Anopheles gambiae s.l. and An. funestus are important vectors of malaria and bancroftian filariasis, which occur as co-endemic infections along the Kenyan Coast. However, little is known about the occurrence and prevalence of concomitant infections of the two diseases in mosquito and human populations in these areas. This study reports the prevalence of concomitant infections of Plas...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Indian journal of medical research
دوره 121 6 شماره
صفحات -
تاریخ انتشار 2005